Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against Schistosoma mansoni, induced liver pathology
Identifieur interne : 000830 ( Main/Exploration ); précédent : 000829; suivant : 000831Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against Schistosoma mansoni, induced liver pathology
Auteurs : Asmaa M. El-Kady ; Alzahraa Abdelraouf Ahmad [Égypte] ; Tasneem M. Hassan [Égypte] ; Heba E M. El-Deek [Égypte] ; Samer S. Fouad [Égypte] ; Sultan S. Althagfan [Arabie saoudite]Source :
- Infection and Drug Resistance [ 1178-6973 ] ; 2019.
Abstract
Schistosomiasis is one of the most prevalent parasitic infections in developing countries. Although chemotherapy is one of the main strategies in controlling the disease, it is less effective in reversal of schistosome-induced pathology especially in the chronic and advanced stages of schistosomiasis. New strategies and prospective therapeutic agents with antifibrotic effects are needed. Eugenol has a wide anti-inflammatory effect. In the present study, we investigated the possible antischistosomal effect of eugenol on
The murine model of
Eugenol treatment showed significant reduction in total worm burden by 19.2%; however, the oogram pattern showed no marked difference compared to that of the PZQ group. Yet, eugenol significantly reduced the serum levels of hepatic enzymes: aspartate aminotransferase and alanine aminotransferase. Histopathological examination revealed a significant reduction in both numbers and diameters of hepatic granulomata, which was consistent with reduction in collagen fiber deposition. Additionally, the antifibrotic effect of eugenol was validated by its considerable reduction in the expression of the sensitive marker α-SMA in both eugenol- and PZQ-treated groups.
Although eugenol could not totally eradicate adults of
Url:
DOI: 10.2147/IDR.S196544
PubMed: 30992676
PubMed Central: 6445185
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against <italic>Schistosoma mansoni,</italic> induced liver pathology</title><author><name sortKey="El Kady, Asmaa M" sort="El Kady, Asmaa M" uniqKey="El Kady A" first="Asmaa M" last="El-Kady">Asmaa M. El-Kady</name><affiliation><nlm:aff id="af1-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, South Valley University, Qena 83523, Egypt,<email>Asmaa.elkady@med.svu.edu.eg</email></nlm:aff></affiliation></author><author><name sortKey="Ahmad, Alzahraa Abdelraouf" sort="Ahmad, Alzahraa Abdelraouf" uniqKey="Ahmad A" first="Alzahraa Abdelraouf" last="Ahmad">Alzahraa Abdelraouf Ahmad</name><affiliation wicri:level="1"><nlm:aff id="af2-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Tasneem M" sort="Hassan, Tasneem M" uniqKey="Hassan T" first="Tasneem M" last="Hassan">Tasneem M. Hassan</name><affiliation wicri:level="1"><nlm:aff id="af2-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="El Deek, Heba E M" sort="El Deek, Heba E M" uniqKey="El Deek H" first="Heba E M" last="El-Deek">Heba E M. El-Deek</name><affiliation wicri:level="1"><nlm:aff id="af3-idr-12-709">Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="Fouad, Samer S" sort="Fouad, Samer S" uniqKey="Fouad S" first="Samer S" last="Fouad">Samer S. Fouad</name><affiliation wicri:level="1"><nlm:aff id="af4-idr-12-709">Department of Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523</wicri:regionArea><wicri:noRegion>Qena 83523</wicri:noRegion></affiliation></author><author><name sortKey="Althagfan, Sultan S" sort="Althagfan, Sultan S" uniqKey="Althagfan S" first="Sultan S" last="Althagfan">Sultan S. Althagfan</name><affiliation wicri:level="1"><nlm:aff id="af5-idr-12-709">Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Munawarah</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30992676</idno><idno type="pmc">6445185</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445185</idno><idno type="RBID">PMC:6445185</idno><idno type="doi">10.2147/IDR.S196544</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000588</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000588</idno><idno type="wicri:Area/Pmc/Curation">000588</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000588</idno><idno type="wicri:Area/Pmc/Checkpoint">000771</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000771</idno><idno type="wicri:Area/Ncbi/Merge">000544</idno><idno type="wicri:Area/Ncbi/Curation">000544</idno><idno type="wicri:Area/Ncbi/Checkpoint">000544</idno><idno type="wicri:Area/Main/Merge">000830</idno><idno type="wicri:Area/Main/Curation">000830</idno><idno type="wicri:Area/Main/Exploration">000830</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Eugenol, a potential schistosomicidal agent with anti-inflammatory and antifibrotic effects against <italic>Schistosoma mansoni,</italic> induced liver pathology</title><author><name sortKey="El Kady, Asmaa M" sort="El Kady, Asmaa M" uniqKey="El Kady A" first="Asmaa M" last="El-Kady">Asmaa M. El-Kady</name><affiliation><nlm:aff id="af1-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, South Valley University, Qena 83523, Egypt,<email>Asmaa.elkady@med.svu.edu.eg</email></nlm:aff></affiliation></author><author><name sortKey="Ahmad, Alzahraa Abdelraouf" sort="Ahmad, Alzahraa Abdelraouf" uniqKey="Ahmad A" first="Alzahraa Abdelraouf" last="Ahmad">Alzahraa Abdelraouf Ahmad</name><affiliation wicri:level="1"><nlm:aff id="af2-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="Hassan, Tasneem M" sort="Hassan, Tasneem M" uniqKey="Hassan T" first="Tasneem M" last="Hassan">Tasneem M. Hassan</name><affiliation wicri:level="1"><nlm:aff id="af2-idr-12-709">Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="El Deek, Heba E M" sort="El Deek, Heba E M" uniqKey="El Deek H" first="Heba E M" last="El-Deek">Heba E M. El-Deek</name><affiliation wicri:level="1"><nlm:aff id="af3-idr-12-709">Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Pathology, Faculty of Medicine, Assiut University, Assiut 71515</wicri:regionArea><wicri:noRegion>Assiut 71515</wicri:noRegion></affiliation></author><author><name sortKey="Fouad, Samer S" sort="Fouad, Samer S" uniqKey="Fouad S" first="Samer S" last="Fouad">Samer S. Fouad</name><affiliation wicri:level="1"><nlm:aff id="af4-idr-12-709">Department of Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523</wicri:regionArea><wicri:noRegion>Qena 83523</wicri:noRegion></affiliation></author><author><name sortKey="Althagfan, Sultan S" sort="Althagfan, Sultan S" uniqKey="Althagfan S" first="Sultan S" last="Althagfan">Sultan S. Althagfan</name><affiliation wicri:level="1"><nlm:aff id="af5-idr-12-709">Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah</wicri:regionArea><wicri:noRegion>Al-Madinah Al-Munawarah</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infection and Drug Resistance</title><idno type="eISSN">1178-6973</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Schistosomiasis is one of the most prevalent parasitic infections in developing countries. Although chemotherapy is one of the main strategies in controlling the disease, it is less effective in reversal of schistosome-induced pathology especially in the chronic and advanced stages of schistosomiasis. New strategies and prospective therapeutic agents with antifibrotic effects are needed. Eugenol has a wide anti-inflammatory effect. In the present study, we investigated the possible antischistosomal effect of eugenol on <italic>Schistosoma mansoni</italic>.</p></sec><sec><title>Materials and methods</title><p>The murine model of <italic>S. mansoni</italic> was established in three groups of adult male Balb-c mice; group I (infected non-treated group) and groups II and III (infected groups) treated orally with eugenol and praziquantel (PZQ), respectively. The expression of the sensitive immunohistochemical marker α-smooth muscle actin (α-SMA) in schistosome-infected tissues was determined. In addition, parasitological, biochemical, and histological parameters that reflect disease severity and morbidity were examined.</p></sec><sec><title>Results</title><p>Eugenol treatment showed significant reduction in total worm burden by 19.2%; however, the oogram pattern showed no marked difference compared to that of the PZQ group. Yet, eugenol significantly reduced the serum levels of hepatic enzymes: aspartate aminotransferase and alanine aminotransferase. Histopathological examination revealed a significant reduction in both numbers and diameters of hepatic granulomata, which was consistent with reduction in collagen fiber deposition. Additionally, the antifibrotic effect of eugenol was validated by its considerable reduction in the expression of the sensitive marker α-SMA in both eugenol- and PZQ-treated groups.</p></sec><sec><title>Conclusion</title><p>Although eugenol could not totally eradicate adults of <italic>S. mansoni</italic>, the significant amelioration of liver enzymes and hepatic fibrosis potentiate eugenol’s role as a promising antifibrotic and a complementary antischistosomal agent.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Quansah, E" uniqKey="Quansah E">E Quansah</name></author><author><name sortKey="Sarpong, E" uniqKey="Sarpong E">E Sarpong</name></author><author><name sortKey="Karikari, Tk" uniqKey="Karikari T">TK Karikari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lustigman, S" uniqKey="Lustigman S">S Lustigman</name></author><author><name sortKey="Prichard, Rk" uniqKey="Prichard R">RK 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El-Kady</name></noCountry><country name="Égypte"><noRegion><name sortKey="Ahmad, Alzahraa Abdelraouf" sort="Ahmad, Alzahraa Abdelraouf" uniqKey="Ahmad A" first="Alzahraa Abdelraouf" last="Ahmad">Alzahraa Abdelraouf Ahmad</name></noRegion><name sortKey="El Deek, Heba E M" sort="El Deek, Heba E M" uniqKey="El Deek H" first="Heba E M" last="El-Deek">Heba E M. El-Deek</name><name sortKey="Fouad, Samer S" sort="Fouad, Samer S" uniqKey="Fouad S" first="Samer S" last="Fouad">Samer S. Fouad</name><name sortKey="Hassan, Tasneem M" sort="Hassan, Tasneem M" uniqKey="Hassan T" first="Tasneem M" last="Hassan">Tasneem M. Hassan</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Althagfan, Sultan S" sort="Althagfan, Sultan S" uniqKey="Althagfan S" first="Sultan S" last="Althagfan">Sultan S. Althagfan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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